As a significant increase of m6A level in response to hypertrophic stimulation, and METTL3-mediated methylation of mRNA is enhanced in response to hypertrophic stimuli and is necessary for a normal hypertrophic response.

We recognized a specific gene highly expressed in cardiac hypertrophy but with hypomethylation.

I wonder how to design the experiments to explain the relationship between Mettl3 and the highly expressed hypomethylated gene.