I would like to know if you could help me with a theoretical problem. I know the proportion of Europeans, Africans, and Amerindians in the population of Rio de Janeiro. I am studying the frequency of certain SNPs in a sample of leukemia patients. Ideally, I should have the frequency of the wild-type and mutated alleles in the population of Rio de Janeiro. However, this information is not available. I have the frequency information for these SNPs in the European, African, and Amerindian populations from the 1000 Genomes project. Would it be sufficient to calculate a weighted average? Do you have any books or articles that discuss this problem? I found many on the opposite scenario, determining the original populations based on a mixed population. Could you provide some guidance?
check dbSNP ,u may find the proportion for each group of population in RIO.
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