The rotary evaporator method is likely the most efficient and gentle option to remove both ethanol and HCl from your mesoporous silica biotin-functionalized nanoparticles. If this is not available, the vacuum oven method can also work well, but air drying in a fume hood is the simplest albeit slowest approach.
Ethanol can be removed via vacuum evaporation, rotary evaporation, or fractional distillation. Residual HCl can be eliminated through neutralization with a mild base, azeotropic distillation, or vacuum drying. Additionally, washing with anhydrous solvents or using desiccants (e.g., P₂O₅, silica gel) can further aid in purification.