How to dissolve Cellulose Acetate Phthalate for encapsulation?

06 February 2025 1 269 Report

Dear all,

I am working on encapsulation of probiotics using Cellulose Acetate Phthalate (CAP). Even though the literature says it can be dissolved in aqueous solutions having mild alkali pH, I am not able to dissolve it.

Is there any tricky part that I should consider?

How can I dissolve CAP?

It can be dissolved in acetone but acetone can damage my probiotics.

Thanks in advance...

Modestas Zilius

Hi Merve kübra Gönen. CAP typically dissolves in an aqueous solution with a pH between 7 and 9. The concentration of CAP also affects its solubility. High concentrations might require longer dissolution times. If you’re using a high concentration, try starting with lower amounts to check solubility first. Perhaps solubility enhancers, such as propylene glycol or PEG 400, could be added.

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