If I choose a certain brain areas, buried pipes （cannula implantation）for drug dose reference only comes from an article on the lateral ventricle injection, we give medicine brain region is different, this article is in ventricle, how do I determine the dose at a certain brain regions to medicine? For example, the BLA.

It is already known that EC50=28nM, and the dose presented in this article is 30 nmol/L in a volume of 5 μL (lateral ventricle).