Hi Kathiravan,
this is not an easy task. If you want to convert the dose from oral to i.p. you need to have in mind a lot of things that happens with the compound that you are applying. I.P. route is convenient for liposolubile compounds but oral route is preferable for drug application in humans. To make my answer shorter: if you dont know the pharmacodynamics and pharmacokinetics of the compound for either of this way's of application it is hard to predict the exact dose that you need to apply.
You can always give several similar doses and check their effects in animals.
all best
Nikola
I think there is no way to convert, and this is the basis of "bioavailability". You must determine the MTD yourself, if it is the first time this compound is used in rats. And even if a MTD has been published it is better to check if it really holds for your animals: we had to reduce the dose of 5-fluorouracil by 20% even if the mouse strain we were dealing with was the same.
Pharmacology is a complex, but very exciting field!
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