I have 9 positron emission tomography (PET) images of a patient, taken at different times. I want to calculate total disintegration (cumulated activity) but I don't know where to begin.
Has anyone came across this topic before? Is there a practical reference or step-by-step guide to it? What tools do I need?
Thank you for your time and attention.
Regards
Dear Sara, i believe you need a Dosimetry SW package which provides you with a workflow for using sequential PET scans (after one therapeutic session) . please start reading Chapter Radiation Dosimetry of PET Imaging
by Dr Mike Stabin. Since i expect you might have "challenges" acquiring clinical products for Dosimetry like from GE and Hermes. On the other hand also non commercial sw exists likeArticle IDAC-Dose 2.1, an internal dosimetry program for diagnostic ...
As employee of GE i like to point at the GE Xeleris platform with its optional Dosimetry package that possibly can be used in handling your data. Good luck
Most PET software can convert your image to units of Bq/cc. Note that 1 Bq = 1 disintegration per second, so you can calculate the total number of desintegrations per cc (centimeter cube) by mathematical integration of the exponential decay equation.
Hi Sara,
To begin with you have to build the time activity curve (TAC) from all 9 points of your data. An x axis for time/ duration while y axis as measured PET data. From there, just integrate the TAC and the total integrate result will be your cumulated activity in activity.time (example; MBq.s). If you devide your cumulated activity with your administered activity, you will get the residence time (for this example in sec). Hope this helps.
Best Regards,
Syahir
- Badges
- Science topic