What is proper injection solvent for drug insoluble in water?

Dear all, I use hydrophobic or insoluble drug for injection What is proper solvent that is low cytotoxicity ?

31 December 2016 2,659 4 View

Oxigen, double bonded to benzene, is carbonyl oxigen?

Dear all, Oxigen, double bonded to benzene, is carbonyl oxigen? (e.g. Phenoxide) Thank you for reading my question.

11 December 2016 9,389 0 View

What is the best solvent for pi-pi interaction of CNT with aromatic compound?

Dear all, What is the best solvent or buffer for pi-pi interaction of CNT? Low polarity solvent is good for non covalent conjugation? I wonder that... Thank you.

11 December 2016 1,968 1 View

Biomolecule and polymer have zetapotetial ?

09 October 2016 9,988 2 View

How nanoparticles bind with thiolated compound ?

06 July 2016 1,485 1 View

Why use coupling reagent [ex) EDC/NHS] ?

Good afternoon :) I want to bind carboxylic acid-SAM layer with protein having amino group. In too many paper, coupling reagent is used for 'activation'. I know that carboxyl group react with...

04 May 2015 3,287 1 View

Is Osmium tetroxide necessary for SEM?

I want to make cell sample for measuring SEM but I don't have osmium tetroxide ( I heard it is expensive reagent...) I have to use osmium tetroxide? or negligible? Are there any other alternatives?

03 April 2015 5,190 6 View

Chlorinated organic formation in odor control scrubbers using hypochlorite?

I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...

03 March 2021 3,661 2 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

How can we theoretically calculate Elemental analysis(percentage) of atoms in covalent organic framework?

For example in one research article the Elemental analysis values of COF-TpPa-1 ( Triformylphloroglucinol (Tp) (63 mg, 0.3 mmol), Paraphenylenediamine (Pa-1) (48 mg, 0.45 mmol) are as follows...

24 February 2021 1,265 6 View

Experimental Design: How deal with pseudreplicates with immunological and clinical-chemical paramaeters?

Hello everybody, I am investigating the influence of a toxinon various clinical-chemical and haematological parameters in fish. I have three treatments (control, low dose, high dose) in my...

24 February 2021 1,243 1 View

How to Control Whiteflies in coconut leaves?

24 February 2021 1,005 1 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

How can we add reinforced thermoplastics with granules in injection molding machine?

I need to make an injection molding machine in which short fibers are to be introduced. Short fiber length and material properties are to be determined and also the material strength are to be...

22 February 2021 4,290 1 View