How to calculate IC50 from Non-linear data?

01 January 1970 1 3K Report

Hello All,

I have done some experiments; checking the inhibitory effect of a drug (Dose-response data). I got Non-linear scatter values as usual. So now, how can I calculate the IC50 value? Can somebody calculate it with due explanation, please?

Rafik Karaman

Dear Salman,

I refer you to two links which list some good answers to a similar question posted on QA section of ResearchGate:

https://www.researchgate.net/post/Can_someone_help_me_to_validate_calculating_ic50_using_raw_concentration_data_and_linear_regression

https://www.researchgate.net/post/How_can_I_calculate_the_IC50_value_using_a_non_linear_model2

Hoping this will be helpful,

Rafik

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