Hi everyone,
I have been trying to figure out a reliable way regarding how to present % intergroup difference of a marker level between study and control groups in a clinical trial and I am confused.
For example, I have come across this study: Valls et al., 2016 (https://sci-hub.se/10.1016/j.phymed.2016.08.007).
Here, they reported an increase in HDL-C in the study group which is from 1.55 to 1.62 mmol/L and a decrease in the placebo group which is from 1.58 to 1.47 mmol/L. In the paper, they also reported a % change from placebo as 14.06%.
Then, I did my own calculations:
* The increase in the study group from 1.55 to 1.62 mmol/L in HDL-C --> +4.52%
* The decrease in the placebo group from 1.58 to 1.47 mmol/L --> -6.96%
Even if I attempt to sum these up (4.52+6.96=11.48%), I still cannot obtain 14.06%. How is this % intergroup difference is calculated?
And statistically what is the more accurate and reliable way of calculating % intergroup difference?
I would really appreciate if you can help me out.
Many thanks to everyone who reads this message!
Hi,
I suggest you see the links on the topic.
Article The use of percentage change from baseline as an outcome in ...
Article Clinical Trial Designs for Predictive Biomarker Validation: ...
https://www.nature.com/articles/s41467-020-17654-y
https://cognivia.com/the-placebo-response-a-phenomenon-related-to-the-placebo-group-or-to-the-individual-patient/
https://www.sabcs.org/portals/sabcs2016/documents/sabcs-2016-abstracts.pdf?v=1
https://mdpi-res.com/d_attachment/ijerph/ijerph-17-01142/article_deploy/ijerph-17-01142-v3.pdf?version=1582719394
Best regards
- Badges
- Science topic
- Similar topics
- Vectorization