Dear Ravi!

Please You look at the following article:

Article Role of CD44 in Regulating TLR2 Activation of Human Macropha...

HA and CD44-specific antibody treatments reduced TLR2 ligand induced NFκB nuclear translocation in THP-1 monocytes and macrophages

Thank you, Alexandr.

Dear Ravi,

Do you specifically wish to block TLR1, or do you want to block the TLR1/2 heterodimer? In the latter case T2.5 in a concentration of 15 µg/ml should work in cell culture, as well as in whole blood of both humans, or mice (but it also blocks the TLR2/6 heterodimer and TLR2 homodimer formation)

E.g. from Hycult: https://www.hycultec.de/hersteller/hycult-biotech/hm1054-5b

I think, the original paper is this: Article Antagonistic antibody prevents toll-like receptor 2-driven l...

thank you, Willem, but I want to selectively block TLR1 is it possible. I am thinking to do with TLR1 antibodies. is it a good idea to do like thay? kindly let me know how to handle this experiment.

Thanking you,

Ravi Prasad Mukku.