Hi everyone. I'm currently working with Dolomite Microfluidic system for preparation on PLGA based microparticles, but I seem to be encountering some issues which have been giving me some trouble for some time already.
1) I'm using a PLGA/DCM solution as my droplet phase and I have a feeling that I'm having a loss of DCM which impacts my particles as the PLGA solution then gets more concentrated.
2) The flow throughout the run is also somehow inconsistent and flow rate starts decreasing and pressure increasing after some time, even though no clogging or blockage is visible under the microscope. I believe this second issue might be related to the first question, despite the blockage also occasionally coming from tubes/pump containing the continuous phase (PVA aqueous solution).
Would anyone be able to help me for a way to reduce this apparent loss of solvent? For information, I use a glass vial that fits into the P-pump pressure chamber, and screw the chamber lid on with the tube placed in the glass vial.
Thanks in advance! - Julia Shih
Try DMSO as a solvent. You get resolved your problem.
Try our PLGA.
www.nomismahealthcare.com.
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