How the metformin reduce the INS gene expression in patients with PCOS ??

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How the metformin reduce the INS gene expression in patients with PCOS ??

metformin a drug that used to reduce the insulin in peripheral blood of patients with PCOS and then reduce of endrogen ; how the metformin reduce the INS gene expression ??

16 August 2019 2,712 3 View

Gene silincing increased with age that caused by hypermethylation : any deases related with hypermethylation in teenage ?

methylation is un important process for gene regulation.

06 May 2018 5,554 4 View

Can FinFET be used in implanted devices?

It is known that FinFET transistor can be used for ultra low power applications. However, I didn't find any research had used this nanotechnology in the biomedical implant applications . is there...

07 August 2017 5,183 3 View

LDPC alternative technique?

Dear researchers, LDPC uses matrices multiplication which makes it complex and power consuming. The question is: Is there any version of LDPC that is less complex or any other efficient coding...

01 February 2017 3,886 0 View

What is the best method for isolate the microRNA??

Genetics

11 December 2016 4,108 0 View

What is the probability distribution of envelopes?

Dear researchers, I hope you can advise an answer or a reference for the following question: For a normally distributed random process, what is the probability distribution of its upper and...

11 December 2016 3,366 6 View

Anyone help me to publish may paper in any journal with impact factor , the journal should be classified in Thomson Roeters

the title is : Identification of Mutations in the coding region of the Human thyroid peroxidase gene in patients with Hypothyroidism.

11 December 2016 8,376 0 View

Alpha stable noise?

Dear researchers, Where the impulsive noise (alpha stable and contaminated Gaussian noise) can be found in real applications? In other words, is there any field where the impulsive noise is used...

31 December 2015 5,663 2 View

What is the effect of mutations that occur in introns?

26 October 2015 6,507 3 View

Periodogram of bimodal distribution?

Dear researchers For iid Gaussian random variable, each periodogram bin is an exponentiallydistributed random variable. Is that hold when we have mixture Gaussian (Bimodal), means, does each...

09 October 2015 6,653 0 View

Why did the authors extrapolate a phenotype that they experimentally proved in one bacterial strain across the whole genus of the organism?

I aim to be as skeptical as possible regarding whether a pair of orthologous genes results in the same phenotype in their different but related bacterial organisms under similar environmental...

05 August 2024 6,787 4 View

Why my colony PCR results of my recombinant bacterial not showing any results?

I am performing ligation of the plasmid and a target gene. The steps I have taken are: 1. Double digestion of the plasmid and target gene 2. Ligation of the plasmid with the target gene 3....

05 August 2024 2,570 3 View

What is saturation solubility of insulin in saliva?? I need it to know sink condition ?

05 August 2024 4,407 0 View

How to increase protein lysate concentration?

I am trying to prepare samples for IP. The pellet size is good and I am using 1% Tx-100 and using a syringe to further lyse the cells and maintain protein-protein interactions. I keep having a...

01 August 2024 7,199 1 View

What is the acceptable p-value cutoff for GO enrichment analysis ?

I have an RNA-seq data that I have analysed using Limma-voom and have extracted the gene IDs, log2FC and the p-values. At p value < 0.05, I have over 10,000 DEGs, however, when I run the GO...

31 July 2024 225 2 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Why cannot i find my protein on cell surface after antibiotic selection of expressing plasmid?

I cannot confirm cell surface protein expression by flow cytometry even after transfection and antibiotic selection of cells. Does it take long for proteins to express on the cell surface? the...

28 July 2024 3,178 3 View

Are these cassettes suitable for expressing PETase mutant in E. coli?

I created two potential gene expression cassettes (constitutive and inducible) for expression of a mutant PETase gene on PeptiCloud using the version tree feature, which allows users to create...

28 July 2024 7,559 1 View

Optimal siRNA Volume for Complexation with Liposomes in a 2.5 mL Solution with 10 mg/mL Lipid Concentration?

How much volume of siRNA can I add to 2.5 mL of liposomes with a total lipid concentration of 10 mg/mL?

27 July 2024 6,920 1 View

If my gene of interest has high GC content can it be problematic in sequencing? What kind of error is expected with GC rich gene sequences??

Gene sequencing related trouble shooting

25 July 2024 4,149 2 View