How the metformin reduce the INS gene expression in patients with PCOS ??

metformin a drug that used to reduce the insulin in peripheral blood of patients with PCOS and then reduce of endrogen ; how the metformin reduce the INS gene expression ??

16 August 2019 2,574 3 View

Can FinFET be used in implanted devices?

It is known that FinFET transistor can be used for ultra low power applications. However, I didn't find any research had used this nanotechnology in the biomedical implant applications . is there...

07 August 2017 4,998 3 View

LDPC alternative technique?

Dear researchers, LDPC uses matrices multiplication which makes it complex and power consuming. The question is: Is there any version of LDPC that is less complex or any other efficient coding...

01 February 2017 3,773 0 View

What is the probability distribution of envelopes?

11 December 2016 3,207 6 View

What is the best method for isolate the microRNA??

Genetics

11 December 2016 4,003 0 View

Anyone help me to publish may paper in any journal with impact factor , the journal should be classified in Thomson Roeters

11 December 2016 8,208 0 View

Alpha stable noise?

31 December 2015 5,528 2 View

Periodogram of bimodal distribution?

09 October 2015 6,507 0 View

Any information about cytosonic mutation ?

introns

09 October 2015 7,141 0 View

How can I calculate the Confidence Interval of decaying trend?

03 April 2015 8,436 2 View

Is it possible for two human neuronal cell lines to have different gene sequence for the same protein?

I am looking at the ATP1A2 (Sodium/Potassium ATPase alpha subunit 2) in two human neuronal cell lines. Expression levels of this protein seems to be almost equal when detected by one antibody....

01 March 2021 3,607 3 View

Genome-wide gene identification protocol ?

Is there any book chapter/book, webpage or research article available to understand genome-wide gene identification?

28 February 2021 8,095 1 View

Any specific pipeline or parameter to analyse total transcriptomics study of brain tissue samples?

I have two groups of brain samples, control and treated for example. It was total RNA nova seq sequencing. I tried all the available pipeline like: star+rsem+deseq2, Hista+stringtie+cuffdiff,...

27 February 2021 356 6 View

Why do my MCFs not form monolayer?

Hello, I am looking for some expertise on culturing MCF7s. I purchased them from ATCC and I have been following all media and culture conditions. Media is EMEM with 10% FBS and 10ug/mL of...

27 February 2021 3,904 2 View

RNA-seq DEGs downstream analysis and reporting in literature?

I used EdgeR to get the list of DEGs (differentially expressed genes) from my liver RNA-seq experiment. I have done the gene overrepresentation and GSEA based pathway analysis. I am currently...

23 February 2021 8,969 1 View

Could you please suggests a tutorial or paper or any other materials to learn multiple gene expression in TCGA and GTEx databases?

I would like to analyze multiple gene expressions in normal and cancer tissue by using the data in the TCGA and GTEx databases. Please suggest a tutorial or paper showing step by step analysis of...

23 February 2021 9,007 3 View

Are there any databases for gene co-expression or expression pattern clustering?

I am currently working on gene clustering based on co-expression pattern in mouse brain. The problem is I do not have some solid way to test my result. Are there any suggestions for databases...

22 February 2021 4,374 3 View

Which CpGs have a significant effect on gene expression?

It is known that methylated CpG around TSS decreases gene expression. However, It is difficult to know exactly which CpG has a greater impact on gene expression. Are there any databases known...

20 February 2021 5,634 3 View

I can detect my protein but the encoding DNA sequence has stop codons within. Should I ignore the stop codons?

I constructed a synthetic DNA library (scFv, VH-VL orientation) with a 3' reporter and 8x histag. I cloned and expressed this gene following which I performed an ELISA. The ELISA results suggested...

19 February 2021 7,006 5 View

Purification of proteins from baculovirus-infected insect cells?

18 February 2021 6,665 6 View