If the intronic alterations are in the regulatory regions, these could affect gene expression levels.Instead if the mutations are in splice sites, protein truncation or non-functional protein could be the result. The phenotype of these alterations depends on how important is the affected proteins or expression levels.
Biju Joseph
As Bijou already mentioned - intronic mutations can affect gene expression levels. There are a few alternative possibilities for that. For example, point mutations (single nucleotide polymorphisms) in introns can introduce novel splice sites, activate novel promoters (which may direct sense or antisense transcription causing alterations in mRNA, miRNA or lncRNA expression), or introduce/eliminate enhancer activity. All these intronic mutations may show up in cell-type specific manner. Insertions/deletions (indels) in intronic areas may carry even more dramatic effects.
BR,
Einari
Generally there should not be any effect as the introns are spliced out. By chance the precision is gone because of mutation 'Simply diseases.' Vast literature is available, if you Google
https://scholar.google.com/scholar?q=mutations+in+introns&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&sqi=2&ved=0CBoQgQMwAGoVChMIiY2Sub2FyQIVE22OCh0ZkwIU
Check the links too you get useful information.
Pre-mRNA splicing and human disease
http://genesdev.cshlp.org/content/17/4/419.full.pdf+html
The Pathobiology of Splicing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855871/pdf/nihms190667.pdf
Effect of Intron Mutations on Processing and Function of Saccharomyces cerevisiae SUP53 tRNA In Vitro and In Vivo
http://mcb.asm.org/content/6/7/2663.full.pdf
https://en.wikipedia.org/wiki/Splice_site_mutation
few months back same question is posed in different style, follow the link
https://www.researchgate.net/post/Do_mutations_in_non-coding_regions_of_a_gene_affects_its_function_and_expression
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