How subcutaneous insulin resistance develops? Any literature confirming its mechanism?

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Suja Karkada

Few review which could help us think are. However it is a rare condition

https://clinicaltrials.gov/ct2/show/NCT00357890

http://care.diabetesjournals.org/content/24/12/2155.full

Mujtaba Hasan Siddiqui

Hope this case report and discussion will help you understanding the mechanism on extreme insulin resistance

http://www.hindawi.com/journals/crie/2013/520904/

Michał Fułek

This publication may come as an answer:

http://diabetes.diabetesjournals.org/content/28/7/640.full-text.pdf

'The increased degrading activity present during insulin resistance had properties not shared with ISP, suggesting the presence of an uncharacterized protease.'