How soon can the baby be breastfed after her mother is injected quinolones? Is the time interval from quinolones injection to breastfeding associated with the T1/2 of quinolones?
If you are referring to the fluroquinolones they are not considered as problematic as people were once concerned about. Feeding 8 hr after an oral administration of meds found none in the breastmilk. If it is possilble for you to access this site it has great information of drugs and lactation and is widely used by physicians and other providers: www.toxnet.nlm.nih.gov/lactmed
The calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk, but insufficient data exist to prove or disprove this assertion. Short-term use of moxifloxacin is acceptable in nursing mothers. However, it is preferable to use an alternate drug for which safety information is available.
Ten lactating women (time postpartum not stated) were given ciprofloxacin 750 mg orally every 12 hours for 3 doses. Milk ciprofloxacin was measured after the third dose. The highest levels averaging 3.79 mg/L occurred 2 hours after the dose. Average milk levels then fell as follows: 2.26 mg/L at 4 hours; 0.86 mg/L at 6 hours, 0.51 mg/L at 9 hours; 0.2 mg/L at 12 hours; and 0.02 mg/L at 24 hours after the dose. All these levels were much lower than the 10 to 40 mg/kg daily used in treating newborn infants.
@Professor Michal Young: Thank you very much! I can access the site www.toxnet.nlm.nih.gov/lactmed and have found some useful information.
In Thomas Hales excellent book Medications band Mothers Milk Ciprofloxacin is rated Moderately safe.The infant should be watched for GI symptoms.If there are none go ahead.Ciprofloxacin is approved by the American Academy of Pediatrics for breast feeding mothers.
In some exclusive condition we use fluroquinolones in newborns, even in prematures. Therefore, this is not barrier for breastfeeding.
Ciprofloxacin is approved by the american academy for pediatrics for breast feeding mother so no problem to use it during this period
Little amount of quinolones , injection or oral may be expressed in the breast milk after administration. The amount is negligible and may not be harmful to the baby. This is an interesting area and if you are a researcher, then a study can be conducted on different types of quinolones, blood level in the lactating mother and level in the breast milk.
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