Hi Dzmitry

This is a rule for Steroids dose reduction, you can apply on the potency of your dosage form and it might be helpful.

Reducing/Discontinuing Steroids

• If taking < 4mg Dexamethasone daily, for less than 3 weeks, steroids can be stopped abruptly. A gradual reduction may be indicated to reduce risk of symptom recurrence.

• If taking dexamethasone for longer than 3 weeks or at a higher dose than 4mg daily, a gradual reduction is indicated. This reduces the risk of symptom recurrence, but also gives time for intrinsic production of steroids to recommence:

# For doses over 2mg daily, reduce by 2mg every 5-7 days

# For doses less than 2mg daily, reduce by 0.5mg every 5-7 days.

• If problems occur during dose reduction, consider increasing dexamethasone back to dose at which symptoms were controlled. Each case should be considered individually.

With my best regards

Could not find any indexed peer-reviewed literature regarding this. It will be interesting to explore the effect of topical steroids on blood pressure and blood sugar in normal population versus diabetics versus hypertensives.

Hi,

Dose of  dexamethasone in an eye drop containing dexamethasone is usually 0.1%. This means that there is 1 mg dexamethasone in 1 ml of eyedrop. Each ml makes 20 drops. So each drop contains 0.05 mg. İf patient is using 4 drops a day, it makes 0.2 mg Dexamethasone per day. Even if all of the drug is absorbed into systemic circulation, it is too small an amount to take into consideration for systemic effects.