Did some research already but didn´t find any real answers so far. I think it differs from tissue to tissue but a approximate answer about how often and at what intervals new proteoglycans and glycosaminoglycans are synthesized in the extracellular matrix would be great.
Thank you in advance.
There is no timetable for glucosaminoglycans synthesis. It depends from tissues and needs. Of course, this is a regulated process. for example in pancreatic cancer the production of hyaluronan is deregulated and excessive. See
Koltai, T., Reshkin, S. J., Carvalho, T., & Cardone, R. A. (2021). Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer. International Journal of Molecular Sciences, 22(8), 3953.
Although this has not been proven, i have the impression that interstitial pressure modulates hyaluronan synthesis. It is produced in the cell membrane of fibroblasts which is sensitive to hydrostatic pressure. Being hyaluronan a highly hygroscopic compound, it increases interstitial pressure on the cell surface.
There is probably a feedback loop that inhibits hyaluronan synthesis when interstitial pressure is high.
I hope this will help you.
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