Hi everyone, I am conducting an experiment which I am extracting substances into a IPA-water mixture. Since I am going to analyse the substances using GCMS, I need to somehow remove the water content from my solution.
I have searched and seen there are methods to do so such as by using extractive distillation but it is quite labour intensive and I also don't want to subject the compounds-of-interest to heat.
Therefore I am wondering whether there is another "easier" way to separate out the IPA-water mixture so that I can have the IPA layer to put into my GCMS.......
Thank you so much for your input.
Max
The most effective technique for eliminating water from an IPA-water blend is extractive distillation. Additionally, alternatives such as liquid-liquid extraction and the utilization of silica gel or Drierite crystals have been proposed as viable methods for water removal.
Can you extract your analytes in something more non-polar such as MTBE? Then you can take the organic layer and inject into the GC, or dry down and reconstitute in IPA if that is an important factor for the analysis.
If your analytes are not volatile you could try evaporation to dryness and then reconstituting in your preferred GC solvent of choice ? Otherwise as others have said, liquid:liquid extraction or SPE are your best choices. Or - try LC-MS ?
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