How many NADPH molecules are required to reduce BH2 to BH4?

Mohammed Noureldin @Mohammed-Noureldin-3

09 September 2015 0 6K Report

Could any one tell me please how many NADPH molecules are required to reduce BH2 (Dihydrobiopterin) to BH4 (Tetrahydrobiopterin) using DHFR (Dihydrofolate reductase)?

In other word, to reduce one mol of BH2 to BH4, do I need two mol of NADPH?

Theoretically as I think it should be 2 molecules, each NADPH molecule will give one hydrogen atom, right? or that can't be calculated like that?

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