How long do the effects of a chronic administration of L-Name last in male rats?

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Candice Pullen

I don't really have a definitive answer on this. I know that when i used L-NAME in wistar rodents for my PhD, they developed hypertension rather quickly. It maybe depend how long you administer L-NAME for? Im thinking that it maybe acutely reversible to a point, however it chronically it may cause irreversible endothelium damage. Is there any published data?

Mireille Kameni

i've just find a publi concerning reversible effetcs after 14 consecutive days treatment, but my own protocol will take 1 month, so I really want to know if after this month of daily administration, i will have no more effects after one-withdrawal additional month?! i will search