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Article The FDA-approved Drug Ivermectin inhibits the replication of...
The FDA-approved drug ivermectin inhibits the replication of SARS ...
Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro. ... Ultimately, development of an effective anti- viral for SARS-CoV-2, if given to patients early in infection, ...
https://www.sciencedirect.com/science/article/pii/S0166354220302011
Please also have a look at the following links.
https://link.springer.com/content/pdf/10.1007/s00210-020-01902-5.pdf
https://www.nature.com/articles/s41429-020-0336-z.pdf
Ivermectin was known to inhibit the nuclear import of viral and host proteins. Integrase protein of viruses and the importin (IMP) α/β1 heterodimer was responsible for IN nuclear import which further increases the infection
https://www.sciencedirect.com/science/article/pii/S2052297520300366
As most of the RNA viruses are dependent upon IMPα/β1 during infection, Ivermectin acts on it and inhibits the import with the increase in antiviral response
https://www.sciencedirect.com/science/article/pii/S2052297520300366
Ivermectin, an antiparasitic drug, showed in vitro reduction of viral RNA in Vero-hSLAM cells 2 hours ... particularly in patients with a hyperinflammatory state possible with COVID- 19.
https://www.medscape.com/answers/2500114-197513/what-is-the-role-of-the-antiparasitic-drug-ivermectin-in-the-treatment-of-coronavirus-disease-2019-covid-19
The readily available anti-parasitic drug has proven effective against Covid-19 in vitro, as well as against other viruses, although human studies are ongoing. The latest research from a team made up of Monash University's Biomedicine Discovery Institute (BDI) and the Peter Doherty Institute of Infection and Immunity indicated that ivermectin could form the basis of a Covid-19 vaccine given that it has proven successful in vitro tests against other viruses, although human studies will be required to test its efficacy against the coronavirus. Ivermectin was first developed in 1975 and came into medical use in 1981. It is on the World Health Organization's List of Essential Medicines. It is currently used as a treatment for strongyloidiasis, a parasitic disease caused by roundworms that affect an estimated 30 million to 100 million people worldwide. Ivermectin is effective in destroying the parasites in the intestine. Whether it will be effective in the fight against Covid-19 remains to be seen but Dr Kylie Wagstaff from the Monash Biomedicine Discovery Institute said on Thursday: "We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it." Dr. Wagstaff cautioned that the tests were carried out in vitro and trials would need to be carried out in people to see if the drug was truly effective against Covid-19.
https://en.as.com/en/2020/04/04/other_sports/1586014265_026414.html
Ivermectin is a easily available anti-parasitic drug that has been used to treat the patients suffering from parasitic diseases globally. The drug has shown promising results against COVID-19. However, in vivo studies can prove its efficacy to treat COVID-19 patients.
Ivermectin is an antiparasitic drug with a broad spectrum antiviral activity invitro, acts as an inhibitor of the causative virus SAR COV 2 with a single addition to VERO-H SALM CELLS 2 H post infection with SARS - COV-2 able to effect 5000 reduction in viral RNA at 48hrs
Kindly check https://www.medscape.com/answers/2500114-197513/what-is-the-role-of-the-antiparasitic-drug-ivermectin-in-the-treatment-of-coronavirus-disease-2019-covid-19
Ivermectin selectively inhibits host importin α/β transporter protein which decreases translocation (shuttling) of SARS CoV nucleocapsid protein (NCP) from the cytoplasm to the nucleus, altered NCP distribution disrupts viral propagation and survival.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434458/
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