I want to know the co-relation between Vitamin D and pancreas. Is there any connecting metabolic pathway or Are there any receptors for VDR on pancreas?
What is the exact mechanism of their co-relation?
One of the relationships between the pancreas and vitamin D is that an enzyme secreted by the pancreas (lipase) is required for the absorption of fat from the small intestine, and since vitamin D is a fat-soluble vitamin, adequate pancreas function (hence adequate lipase availability) is unnecessary for the intestinal absorption of this vitamin. I hope this helps?
Increasing evidence suggests that vitamin D exerts multiple effects beyond bone and calcium metabolism. Vitamin D seems to play a role in pancreatic disease, including type 1 and type 2 diabetes mellitus as well as pancreatic cancer and pancreatitis (Vitamin D deficiency). Vitamin D's immune-modulatory action suggests that it could help prevent type 1 diabetes. In type 2 diabetes, vitamin D may influence β-cell function, insulin sensitivity, and systematic inflammation-all characteristic pathways of that disease. Data from observational studies correlated vitamin D deficiency with risk of type 1 and type 2 diabetes. Prospective and ecological studies of pancreatic cancer incidence generally support a beneficial effect of higher 25-hydroxyvitamin D concentration as well as inverse correlations between UVB dose or exposure and incidence and/or mortality rate of pancreatic cancer. For detail, see https://www.ncbi.nlm.nih.gov/pubmed/27030935Article Vitamin D deficiency predicts severe acute pancreatitis
https://www.wcrf.org/int/research-we-fund/what-we-re-funding/vitamin-d-and-pancreatic-cancer-risk
https://www.longdom.org/open-access/vitamin-d-deficiency-in-patients-with-pancreatitis-is-vitamin-d-replacementrequired-2165-7092-1000172.pdfo
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