I am currently working on Solid lipid Nanoparticles. On what bases do I decide which lipid to be chosen from the list of lipids given in the papers... Solubility tests, DSC, TGA will any of these test help me decide which lipid has to be picked up ?
We had similar discussion for the selection of lipids in previous section also.
https://www.researchgate.net/post/Which_type_of_lipids_are_used_for_Solid_Lipid_Nano_particle_preparation
Also there here are some articles which may be helpful.
1. http://onlinelibrary.wiley.com/doi/10.1002/ejlt.201200240/epdf
2. http://www.jpsr.pharmainfo.in/Documents/Volumes/vol4issue07/jpsr%2004120702.pdf
If you also need some for preparation method, go through
1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131401/
2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865805/
If you want to obtain nanoparticles of lipid from nanoemulsion (miniemulsion polymerization), is very important the facility of the breaking of the lipid drops for obtaining the miniemulsions, because from it will depend the particle size and colloidal stability. Lipids with low viscosity is preferred if you will employ miniemulsion polymerization.
As per my understanding, there is no general rule for selection of lipids in formulation and development of lipid nanoparticles.
Its all depends on your objective of the study.
eg. If you plan to prepare a SLN for control release, and your drug has a very low dose- in this case solubility is not a major issue, you should select the lipid which is capable of giving control release and also can encapsulate the required dose.
Like this you have to balance/optimize particle size, drug loading, entrapment efficiency, drug release etc. For optimization of all this parameters; I think DoE can help a lot.
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology