It has been long known that collagen matrix can chelate with metal cation like calcium and chromium. That is one way to mix hydroxyapatite with collagen.
But for biomaterial, how exactly is the releasing curve of the ion (eg. Ca2+) from the collagen, in vitro and in vivo? Does it burst and leak very fast just like growth factor in collagen? or can it be retained and release more smoothly? Are there any studies on this?
Thank you!
Generally speaking the interactions between collagens and calcium ions are very stable (chelates). On the other hand considering that the collagen family is composed by at least 28 components (Cold Spring Harb Perspect Biol 2011; Sylvie Ricard-Blum) the composition of the collagen biomaterial might affect the interactions with this ion as well as its aggregtion state (soluble, gel, polymeric, insoluble, etc). A recent paper could be useful to enlighten these aspects (Sci Rep 2017: Pang, Ligun & Tang).
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