Hi everyone,
Perhaps this is a stupid question but it came across my mind that it is much easier to evade immune recognition of antigen derived from immune privileged sites such as the brain, the bone marrow and the placenta. How do these sites not having higher chance of developing tumor than other organs? Please share with me your idea. Thanks so much
Dear Dung,
a recent discovery of lymphatic vessels lining the dural sinuses and directly connecting the nervous and immune systems strongly supports a tight molecular exchange between the brain and the immune system. This new anatomic finding brakes the classic assumption of the blood–brain barrier, and allows new hypothesis on the pathogenesis of conditions involving the immune and nervous systems
Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature 2015; 523: 337-41. PMID: 26030524
Best Regards,
Cristina
Dear Dang,
I agree with Cristina. There is no completely secure area in the body to escape from immune system. The privileged sites are privilege for normal circumstances by lack of large lymphatic vessels, Fas-FasL induced apoptotic capability or their suppressor/regulatory microenvironment. But, if develop any tumor in privileged site, the rules are change and immune attack develops.
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