The surrogate marker HOMA - IR which we apply to human beings cannot be applied in animal experiments, because the baseline glucose and insulin values differ for each species. Given this, how HOMA - IR can be calculated in swiss albino mice?
Dear,
In Swiss Albino mice, insulin resistance is estimated using the homeostasis model assessment for insulin resistance (HOMA-IR) index using the formula described previously by Mathew et al., HOMA-IR index = [fasting glucose (mmol/L) × fasting insulin (mU/ml)].
See this paper:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074064/pdf/pone.0100562.pdf
Dear Gnanagurudasan
HOMA-IR basically states that the response of insulin with glucose homeostasis.
So you can apply same formula derived from Mathews et al.
Dear Gnanagurudasan,
Find the article regarding the same:
http://www.omicsonline.org/essential-oil-of-cymbopogon-citratus-against-diabetes-validation-by-in-vivo-experiments-and-computational-studies-1948-593X.1000098.php?aid=22036
Regards
Sudhanshu Bharti