What is the mechanism and the protein domains involved in stripping heme or iron from protein complexes?

Article Molecular Mechanisms of Bio-Catalysis of Heme Extraction fro...

Hi there,

Heme binding to hemoglobin is non covalent.

Thank you!

So when it goes to more "tight" binding between Heme and cytochrome C? Is there any research on this topic?

Article Heme Synthesis and Acquisition in Bacterial Pathogens