Take this example (Bisoprolol is the mentioned example ) : assuming that 5 mg is the minimum effective dose
dosing with 5 to 20 mg, and mean peak values range from 16 ng/mL at 5 mg to 70 ng/mL at 20 mg. So 5 mg dose will give a range of concentrations that are therapeutically active ranging from 16 ng/ml to 8 ng/ml , etc.. So how they are equating both terms minimum effective and minimum effective concentration although 5 mg will give a range of concentrations that will be active not like mec which is below which no activity ?
Minimal effective concentrations is obtained 5mg so the response will be produced but the magnitude of effects is dependent on receptor occupied whileincreasing the dose to 20mg will raise the plasmaconcentrationof the drug that will occupy most of the receptors so the magnitude of effects will be increased .
further you can read from the Katzung basicand clinical pharmacology or further elaborate your question.
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