How does the hormone production by GCTs influence their clinical detection, and what symptoms might prompt earlier diagnosis?
GCTs are hormonally active tumors, often producing estrogen, which can lead to clinical symptoms such as abnormal uterine bleeding, endometrial hyperplasia, or even endometrial cancer. In younger patients, estrogen production may cause signs of precocious puberty. These hormone-driven symptoms can prompt earlier clinical detection, leading to diagnosis at an earlier stage compared to non-hormonally active ovarian tumors. Estrogen overproduction in postmenopausal women can also present as unexpected vaginal bleeding, which often triggers further investigation.
GCTs are hormonally active tumors, often producing estrogen, which can lead to clinical symptoms such as abnormal uterine bleeding, endometrial hyperplasia, or even endometrial cancer.
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