It is known that 1-2 nm zinc metal nanoparticles being added with odorant significantly enhance sense of smell. We can speculate that zinc nanoparticles play the role of electron donors in the interaction with olfactory receptors (Turin L. A spectroscopic mechanism for primary olfactory reception. Chemical Senses. 1996;21(6):773-91). We see that only small nanoparticles, smaller than 4 nm are physiologically active. Is there any physical rational for the size dependence? I guess, it should be a discrete dependence, not continues, as everything in a quantum physics. Good reference?