According to Robbin's Pathology, hyperthyroidism leads to an overactivity of the sympathetic system.
It also goes on to mention that this sympathetic hyperstimulation in the gut leads to increased motility leading to diarrhea and malabsorption.
How would sympathetic stimulation cause hypermotility? Isn't the parasympathetic system responsible for it? I've read further that it rather is hyperdefecation. Does it make a difference?
Also, how does hyperthyroidism increase the sympathetic tone?
The adrenergic system stimultion leds to diarrhea nd the correction of transit time in hyperthyroid patients is much improvved witth betablockers.
Gastrointestinal motor dysfunction is widely accepted as the main cause of symptoms in hyperthyroidism. Again, Intestinal hypermotility in thyrotoxicosis reduces small bowel transit time, especially when diarrhea is present. Increased appetite and excessive fat-rich food intake may contribute to excessive fecal fat. Moreover, diarrhea may be related to a hypersecretory state within the intestinal mucosa. The adrenergic system may contribute to diarrhea as suggested by correction of transit in hyperthyroid patients treated with the β-adrenergic antagonist propranolol. A reduction in mixing of food with digestive secretions may also contribute to decreased fat absorption.
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Pharmaceuticals
- Drugs