In my view, The loss of color information may lead to visible artifacts, such as color bleeding or blockiness, especially in areas with rapid color changes. These artifacts are more noticeable in images or videos with fine color details or gradients.

Indeed, chroma subsampling is a compromise between efficient data representation and color accuracy. The choice of subsampling ratio depends on the specific requirements of the application, the characteristics of the content, and the acceptable level of visual quality for the intended audience.