How does bis(4-nitrophenyl)-phosphate (BNPP) act in chemotherapy?

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Cristiano Ferlini

BNPP is a specific inhibitor of carboxylesterase (CE). BNPP affects the metanolism of chemo such as Topo-I inhibitors and has been used in animal models to modulate the effects of chemotherapy when CE activity is high.

http://imr.sagepub.com/content/33/1/84.full.pdf

Nupur Raychaudhuri

Thank you Cristiano.