What are the practical ways to manage erythematous skin rash due to Azacitidine? This is different from skin irritation at the injection site, which is usually mild and self-limited. I have seen patients who develop generalized patchy erythematous skin rash which is pruritic.
I try to continue Azacitidine, and use topical steroids and short course of oral Prednisone. I wonder if any of you has had the same experience.
Dear Akhtari from a dermatological point of view Azacitidine was the apparent cause of Sweet's syndrome where it responded well to corticosteroid therapy.
Dear Akhtari, Azactidine can cause febrile neutrophilic dermatosis 'Sweet's syndrome', erytematous and tender skin lesion with dermal infiltration of neutrophil. symptoms and lesion can be imroved with the systemic corticosteroids. high potency topical corticosteroids may successfully treat localised manifestation of Sweet's syndrome.
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