How do you determine the core-shell structure of nano-scale capsules clearly?

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Ankur Shah

One of the best way would be stain you NPs with staining agent (osmium tertraoxide, you can find some biocompatible staining agents) and then run a TEM scan not SEM, and you will have a perfect core shell NPs.

The staining agents would induce contrast in of the either Core-shell materials

Arun Karthick

TEM characterization helps you to get the core-shell structure.