How do we estimate the bioavailability of phytochemicals soluble in pentane?

More Sujith Subash Eranezhath's questions See All

How can I Model a Direct Drive PMSG Wind Turbine ?

Hello All, I am trying to test the performance of a motor(CMP80M - Sew Eurodrive - PMSM) as a generator in case of a Wind Turbine system. I have already implemented the dq equations of a PMSG for...

29 April 2019 9,445 1 View

Porous media combustion in FLUENT or CFX ?

How to do simulation in PMC to get mass fraction of hydrogen from Biomass combustion using FLUENT or CFX with cad model of combustor?? Is there any specif papers available.. help me

02 April 2019 5,071 2 View

What are the possible phytochemical groups that can get soluble in ethanol and hexane extracts?

During extraction of herbal material in ethanol and hexane what are the group of phytochemicals that we can expect to get soluble in it?

21 March 2018 3,120 7 View

Someone there doing colchicine extraction from Gloriosa superba?

How difficult the extraction process is? Can anyone share me the working protocol to learn the procedure? To establish a start up, what all are the required equipment initially?

01 November 2017 8,380 2 View

A right circular polarized(RCP) light changes to LCP after reflection from a medium of higher ref. index, but does it differ with angle of incidence?

Actually my concern is for the reflection from a Silver/Aluminium mirror, at an angle of incidence of 45 degrees. And the wavelength is in the visible range.

22 February 2015 8,285 7 View

How do I take my methanol soluble substance to MTT assay to test the effect of this substance on my cell cultures?

The unidentified substance of my interest derived from a plant is only methanol soluble. how would I do MTT assay using this substance of my interest?

27 June 2014 6,725 3 View

Can someone suggest a mechanical device with two inputs for pressurized gases and one outlet with constant pressure output?

I need 2 gases with diff. pressures to enter into a chamber, combine and come out with a required pressure (that required pressure will be set by me). The input pressures may not be always...

01 August 2013 3,285 9 View

Can anyone suggest an inexpensive way of liberating hydrogen from water?

An instantaneous, continuous and pure production is required.

18 July 2012 3,483 15 View

embedded systems

Hi,I am new to the group.I am currently working as a software professional in IT I want to be a embeddded software developer.Can any one tell me how to step into the embedded field?

25 May 2011 3,895 25 View

How can plant phytochemistry be included in discussions about whole plant traits?

I am using the concept of plant functional traits (Cornellisen et al., 2003) in a paper. Considering descriptions for whole plant traits (life history; life form; growth form; plant height;...

24 February 2021 6,831 5 View

Possible reasons for high bioavailability after I.M and S.C. routes...?

What should be the possible reasons if we obtained more than 100% bioavailability of antibiotics (marbofloxacin) after I.M. and S.C. routes of administration in cattle species.

16 February 2021 971 4 View

Phytic acid limits bioavailability of micronutrients: Is challenge for biofortification?

As many researcher have confirmed that phytic acid content basically present in cereals and legumes crop that responsible for limiting bioavailability of micronutrients (Fe and Zn) in seeds. Lets...

31 January 2021 5,556 8 View

What is the better option to improve immunity ? Medicine or diet ?

What is the better option to improve immunity ? Medicine or diet ? As per Ayurveda, Oja is the Bala (~immunity) which is originated by the Ahara which further nourishes Rasa, Rakta etc Dhatu and...

21 December 2020 4,427 10 View

What is the chemical composition of Cucumis melo roots?

I have found an old pharmaceutical research from 1833 in which emetic power of Cucumis melo roots was confirmed. I cannot find data about chemical constituents of the Cucumis melo roots. Their...

30 October 2020 3,633 3 View

Can reduced particle size increase solubility ?

I'm trying to make Nanostructured lipid carriers (NLC) using ultrasonicator method for cancer meds that are hydrophobic and insoluble in water. I'm heating solid and liquid lipid phase and then...

21 October 2020 9,081 5 View

How do you extract a specific chemical from a plant?

I know how to get the general extract from a plant - I can get the total phenols, alkaloids, Flavanoids, etc, but I want to isolate just one particular phenolic compound from the total extract....

21 October 2020 6,384 19 View

Curd intake advisories in Traditional System of Medicine?

Ayurveda, TM of India, advises to avoid Curd intake in diseases that have Kapha dosha predominance like Diabetes, Respiratory problems; in diseases arising out of Raktha dusti (Blood tissue...

03 October 2020 780 1 View

What is the best method and solvent for isolation of alkaloids from leaves?

my target to isolate alkaloids from plant leaves, as phytochemistry of plant reported for some alkaloid derivatives , so please guide me.

01 August 2020 7,376 15 View

Are drugs that are susceptible to first pass metabolism readily excreted?

first pass metabolism decreases bioavailability and can increase elimination but does it increase excretion of susceptible drugs

22 July 2020 9,313 3 View

Francisco Erik González Jiménez

You try dissolve the extract lyophilized in tween 80 or 40.

Sujith Subash Eranezhath

@Francisco Erik, and then how do we proceed? Is there any protocol?

Adam J Smith

If your question concerns dosing, you can create a homogenous suspension using a methylcellulose and tween 80 vehicle. Alternatively, my lab has used corn oil as a vehicle for poorly soluble phytochemicals.

@Adam Smith, It is interesting to note pentane soluble components would be soluble in corn oil, can you give some details on how is this done and how can we make sure it is bioavailable. Please also share if any papers are available on details of using corn oil. Thanks!