The formula for converting oral dose to inhalation dose:
D(inhalation)= D(oral) * (bioavailability for inhalation/ bioavailability for oral administration)
if the bioavailability for inhalation not available in literature, how do i calculate the inhalation dose? any other method to calculate the inhalation dose?
Thank you
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Alternatively, you could try building up your model graphically with Phoenix's NLME tool if you have access to this engine as I find it more user friendly. Then you could estimate bioavailability.
https://support.certara.com/forums/topic/558-absolute-bioavailability/?p=2191
If you really have no idea of bioavailability(?similar compounds, formulations.) then you could at least simulate a few different scenarios to see what might be a safe dose for FIM.
Simon.
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