I am seeking information and relevant literature on the comparison between free and total oxylipins across different biological matrices, such as plasma and tumor tissues, particularly in relation to disease mechanism understanding.
Additionally, I would appreciate any insights into the various carriers of oxylipins within the body. Specifically, I am curious to know whether lipid droplets serve as one of these carriers.
Any guidance, references, or shared experiences would be greatly appreciated.
Total and free oxylipin profiles provide complementary insights into disease mechanisms such as cancer. Free oxylipins represent bioactive lipid mediators immediately available to interact with cellular targets, influencing inflammation, cell proliferation, and apoptosis. In contrast, total oxylipins (which include both free and esterified forms) reflect the overall oxylipin reservoir, including those stored in complex lipids and membranes, indicating potential for release and sustained signaling.
Comparing profiles across biological matrices like plasma and tumor tissues helps reveal local vs. systemic lipid mediator dynamics in cancer progression. Oxylipins are transported not only freely in plasma but also bound to carriers such as albumin and incorporated into lipid droplets, which serve as reservoirs regulating their bioavailability and activity.
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