I am interested in understanding the actions of SERMs such as Tamoxifen and its metabolite 4OHT on GPR55, especially in the breast cancer cells which express GPR55. Since exploring CBD as an antagonist on GPR55 in breast cancer as an antiproliferative agent, we must understand how other substances interact with it. Since SERMs show great affinity for CB1 and CB2, I must wonder about GPR55. Thank you for your consideration.
May be the following publication can help you: https://academic.oup.com/annonc/article/24/7/1867/190724/Genome-wide-discovery-of-genetic-variants
I have some experience with tamoxifen in breast cancer, but with its metabolites I do not have!
I will Folowe this discussion and I think it will be very useful to me, on this topic!
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