Depending on the detector you have, it is possible. If it is a uv detector, first make sure that your compound of interest absorbs in the uv region or run a standard sample in the HPLC and get the retention times. Extract your soil samples using any literature method, mostly we use a soxhlet extractor with organic solvents for most pesticides, unless your compound of interest is polar. Using external standards, determine the standard curve for various concentrations before determining your unknowns.

Vaibhav,

What detectors are available to you?  Are you interested in focusing on a single parameter like PAH's, or Explosives? - carbamates or organochlorine pesticides, herbicides?  Each class of compound would require a different extraction and analysis method.  Much to complex for a single "HPLC" method.  It is best to initially characterize your solid waste (soil) to determine what is there.  Then apply the appropriate analytical method to quantitate the contaminant.

Here are a couple of really good sites to get you started.

US EPA NEPIS site -  Just search on your compound of interest, FYI if you just type in HPLC as a search parameter you will get 2,140 publications.

http://www.epa.gov/nscep/  

NEMI is another good one (National Environmental Methods Index). Just typing in HPLC returned 134 HPLC methods for environmental analysis.

https://www.nemi.gov/home/

Yes. It Is possible through HPLC.  Just you may compromise with the detection limit.  What kind of detection limit are you looking for?

Dear Vaibhav Kumar Nain,

Yes, it is possible to analyse the organic compounds in soil by chromatography techniques, and you can determine in qualitative and quantitative of different organic compounds like: HAPs. phenols....

Different steps process in the analytical method, you should start: 1) preparation of sample 2) extraction of your analyses of soil sample (using Soxhlet with organic solvent), 3) cleanup, 4) concentrating your extract (reduce volume), 5) added an appropriate internal standard, 5) data analysis (chemstation) .

in chromatography analysis, using the HPLC procedure should consider different parameters in HPLC procedure like: mobile phase solvent ratio, column type (C18 or C8 or other specific column), wavelength detection, flow rate, UV detector or DAD detector.

Also for qualitative analysis you need appropriate external standard and for quantitative analysis you need an internal standard.

 Yes, it is possible with HPLC just make sure to use the appropriate solvent(s) for extraction. The choice of solvent depends on the properties of the chemicals (from the soil) that you want to extract from the soil and quantify through HPLC. You may want to consult related literature for that.