It seems that long-time sonication will accelerate aggregation, but insufficient sonication cannot disperse the nanoparticles well. Does anyone know the best sonication time ( either using probe or bath) to disperse copper NPs or CuO-NPs?
Hi Xiaoyu,
Deciding how much time nanoparticles suspensions should be sonicated for could be a little tricky. As you may have noticed, different groups do different things. I suggest you consult previous publications that claim to have successfully dispersed the particles. For instance, we successfully dispersed CuO nanoparticles in our recent work (see attached). Of course, published methods may not necessarily work for your system, especially if the particles were made via a different method but it is always a good place to start. With a bit of additional trial and error you will find the "sweet-spot" for your system. I always start with 30 min bath sonication with or without 2 sec probe sonication... you can start from there.
Best wishes.
Thanks Dr. Adeyemi! Actually I have reviewed your article. I use the same CuO-NPs with you in your research ( purchased from US research nanomaterials. inc) . Actually I send an email to Professor Keller about the details in making the suspension. I use the 0.5 mM phosphate buffer and nano pured water to disperse CuO NPs in my system ( concentration is 200ppm). But I find that after 30 min bath sonication ( and actually we use the same type sonication bath), I still can not get prefect dispersion. I can see small particles are still stick together, and the quality result of zetesize told me my system may have some really large particles. So when you disperse the CuO-NPs, do you have the same problem ( some large particles exist in the suspension)? I also try the probe sonication , it seems the particles can be dispersed well, but only after 10 min you can see the particles stick together again..
Hi Xiaoyu,
So what we did was a combination of bath and probe sonication (see the full description in section 3.0 of the SI). Stocks were made at 200 ppm in nanopure water only (no buffer at this point) but final concentration that was measured was 50 ppm. Final volume that was measured was 1 mL; and buffer was added to the nanoparticles (to make 0.5 mM) just before DLS analysis. In addition to bath sonication, the 1 mL was probe-sonicated for 5 s and measured immediately.
Please let me know if you have more questions. I am more likely to answer my emails faster though.
bonjour
je pense qu'il faut voir les études réalisées sur l'optimisation par ta technique de plan d'expérience.
Sir, can you provide me this attachment , I tried opening it but it is not available I guess.
Adeleye et al 2014.pdf
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Adeyemi S. Adeleye
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