I have some chlorhexidine with some impurities with it like
A: 1-(4-chlorophenyl)-5-[6-(3-cyanoguanidino)hexyl]-biguanide
B: [[[6-[5-(4-chlorophenyl)guanidino]hexyl]-amino]iminomethyl]urea,
C: 1,1¢-[hexane-1,6-diylbis[imino(iminocarbonyl)]]bis[3-(4-chlorophenyl)urea],
D: 1,1¢-[[[[[(4-chlorophenyl)amino]iminomethyl]-imino]methylene]bis[imino(hexane-1,6-diyl)]]bis[5-(4-chlorophenyl)biguanide].
and I want to characterize and/or determine the kinds and concentrations of impurities.
So, I would be great-full if someone could give me a method on GC or HPLC that I can apply for these compounds.
A complete method please with all the details?
HPLC method is the best, several methods are reported in articles. Here is one.
http://link.springer.com/article/10.1023%2FA%3A1018986501194
Dear Mr. Jobdevairakkam,
I appreciate your highly helpful answer. Especially the attached paper.
I think this is the right thing that I was searching on.
Cheers,
M Ramezani.
Chemical constituents can be identified by using a gas chromatographer coupled to a mass spectrometer system. I have used this model: GC–MS, Shimadzu, model QP 5050, Japan. Good luck!
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