Determining tumor volume is a useful and quantitative way to monitor tumor progression? What is the best or known methods to calculate NPC tumor volume
Tumor volume = 1/2(length × width^2)
measure length and width with calipers.
I also have used this to calculate tumor mass,
Tumor volume = 1/2(length × width^2), final as mm^3
Daily if possable, for sub-Q tumors.
I have not tried, but see online:Tumor volume in subcutaneous mouse xenografts measured by microCT is more accurate and reproducible than determined by 18F-FDG-microPET or external caliper
Mette Munk Jensen1,
The usual method is a daily calipser measurement, since the tumor obeys a circunferencial growth. Image methods as CT, cintigraphy also can do it, but a little few labs have these expansive methods. The most important , in my point of view, are the method must the same and must be doing by the same person. Overall the statistical analisys must make do considerng that the initial number of tumor graft are diferent, so the use of comparative analisys is insuficient to understant the tumor dynamic growth, that have a great importance in results interptetation. To do the statistical analysys I suggest a regression method.
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