In investigating collagen I got quite puzzled. Could you please offer me some advice? Here are some of my questions
1. In heterogenous tissue engineering, collagen seems to be potentially the backbone material, as PCL and hydroxyapatite for osteo-regeneration. How is the comparison of collagen with other alternatives (Poly(ethylene glycol), fibronectin, other protein and synthesized peptide like BiogelX)?
2. For the core issue in collagen biomaterial study, actually existed crosslinker (EDC/NHS, genepin, TG2) already meets most basic needs (stability, mechanics, cytotoxicity), aren’t they? The core issue has swifted to realise reconstruction of better microenvironment of different tissue, has it?
3. What are the critical requirements for collagen product (stability/rentation of triple helix, chain length, bound water, solubility and ?)? and how are the influences of these properties on biomaterial application? (swelling, porosity, mechanic property and fidelity, immuno-rejection, biodegradation and etc)
Thank you very much!
Dear Zonghan, maybe, this paper would be useful for you: Article Medical Applications of Collagen and Collagen-Based Materials
Dear Zonghan Gan,I hope the article will be useful to you:
10.1186/s12938-019-0647-0
Dear Zonghan Gan,
Great thought! It has been more than several decades people study about the collagen properties from various sources and now researchers worldwide focus on marine, avian, mammalian etc. Currently, I am working with ovine collagen and natural crosslinke of genipin. We are moving now towards MDA approval for clinical use.
If you are really like to explore more on collagen, you may look for inflammasome, short term and long term effect e.g cancer formation etc...If you like to discuss more you could email me. Best of luck!
Dear Gan,
Refer the site given below which illustrates the full seen of collagen processing.
https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/s12938-019-0647-0
Collagen-based medical products, which are offered on the market, are purified and prepared by routine technologies. They are applied successfully in reconstructive surgery, and the range of possible applications is further increasing.Major challenges for processing is mechanical stability and vascularization of the hybrid materials consisting of many structural elements.
Ashish