There seems to be a lot of work on how drugs get through the outer membrane of gram-negative bacteria, but relatively little is known (or at least published) regarding how drugs cross the inner membrane of gram-negative bacteria as well as the single membrane of gram positive bacteria. Is it just based on trial and error and if the drug works then who cares how it got in?
Normally uptake happen through porin channels using mostly Zn cation chelation. The small drug molecule should not be the substrate of efflux pumps. Otherwise you need to add EPInhibitor. If details are required I can speak to my microbilogy colleauges and convey you.
Thanks for the info. However, I believe porins are mainly in the outer membrane. I'm interested in how antibiotics get through the inner membrane. Any info you can provide would be much appreciated.
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