How could I improve the process of reconstitution of nanoparticles?

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Omar Gonzalez-Ortega

After drying it will be very difficult to redisperse. Are you sonicating the sample? Were the silica particles protected before drying?

Syed Salman Hashmi

Adjusting the pH and sonication followed by vortexing might help.

If sonication will favor the release of the drug then the system is not properly designed. Anyway any peg derived surfactant might help. Do not dry the sample if possible.