1- Recently a new technique has been found using cooling devices to prevent hair loss in cancer treatment.
2- Sometimes, the tumor size can be first reduced using radiotherapy or surgery to prevent use of higher doses of chemotherapy leadding to reduced side effects.
3- Novel drug delivery systems having targeting moieties are being studied for higher efficacy as well as lower side effects.
There is a lot of clinical (and limited preclinical) evidence about short term starvations (1-3 days, which, applied before starting chemotherapy, can prevent or significantly reduce the chemotherapy related side effects. The propised mechanism of action is mediated via Insulin Growth factor 1 which is switching normal tissues into a "resting" means protected cell metabolism mode, while activation the tumor cells into a more chemotherapy sensitive status. Just look for Short term starvation, Chemotherapy and IgF 1
Oman Med J. 2014 Nov; 29(6): 391–398.doi: 10.5001/omj.2014.107PMCID: PMC4289501PMID: 25584154
Starvation Based Differential Chemotherapy: A Novel Approach for Cancer Treatment
Sidra Naveed,1 Muhammad Aslam,1 and Aftab Ahmad2,*Author information Article notes Copyright and License information DisclaimerThis article has been cited by other articles in PMC.Go to:
Abstract
Cancer patients undergoing chemotherapy treatment are advised to increase food intake to overcome the therapy-induced side effects, and weight loss. Dietary restriction is known to slow down the aging process and hence reduce age-related diseases such as cancer. Fasting or short-term starvation is more effective than dietary restriction to prevent cancer growth since starved cells switch off signals for growth and reproduction and enter a protective mode, while cancer cells, being mutated, are not sensitized by any external growth signals and are not protected against any stress. This phenomenon is known as differential stress resistance (DSR). Nutrient signaling pathways involving growth hormone/insulin-like growth factor-1 axis and its downstream effectors, play a key role in DSR in response to starvation controlling the other cell maintenance systems, such as autophagy and apoptosis, that are related to the tumorigenesis. Yeast cells lacking these effectors are better protected against oxidative stress compared to normal cells. In the same way, starvation protects many cell lines and mice against high-dose chemotherapeutic drugs. According to a series of studies, fasting results in overall reduction in chemotherapy side effects in cancer patients. Data shows that starvation-dependent differential chemotherapy is safe, feasible and effective in cancer treatment, but the possible side effects of starvation limit its efficacy. However, further studies and clinical trials may result in its implementation in cancer treatment.
There is a long list of side effects of chemotherapy, and each group of chemotherapeutic agents might have different side effect than other group(s)! Therefore, it depends on what type of side effect that you want to minimise, as many adverse effects can be managed medically.