Suppose, if we take 2 gm of Raw MAI (yellowish in color) in 20 ml ethanol then how much Diethyl ether should be added in solution of recrystallize all of (2 gm) MAI (white color).
It's known that the quality of crystals depends on many variables including temperature, concentration, solvent (nature and/or ratio), pH and ionic strength. Since all of these parameters cannot be fully controlled during the crystallization procedure, crystallization seems to be more an art then a science. This means that one should optimize crystallization parameters by trial-and-error procedure. So you need to proceed by trial-and-error to optimize the amount of Diethyl ether you need. In addition you may use different crystallization techniques such as hanging drop, sitting drop, slow diffusion, slow cooling and slow evaporation.
I agree with M. Mangwala. May I just complement his information: When you crystallize by anti-solvent addition stirring, point and speed of anti solvent addition i,mpacts on the process rate and product quality. As M. Mangwala told you have two choices to know the amount of anti-solvent necessary: the first one is to know the three component equilibria diagram (that, probably may be difficult to find for some systems) or experimentally.
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