How can one determine the pka of a biological polymer?

16 December 2013 1 8K Report

Polymers.

Techniques like potentiometry, spectrometry, voltammetry, electrophoresis,calorimetry even NMR can be used to determine PKa..

In your case of peptides and amino acids, PKa value depends on the type of ionizable groups, see this link:

http://web.chem.ucla.edu/~rebecca/153A/amino_acids.pdf

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